Today’s food and farming systems have succeeded in supplying large volumes of foods to global markets, but are generating negative outcomes on multiple fronts: widespread degradation of land, water and ecosystems; high GHG emissions; biodiversity losses; persistent hunger and micro-nutrient deficiencies alongside the rapid rise of obesity and diet-related diseases; and livelihood stresses for farmers around the world. Many of these problems are linked specifically to ‘industrial agriculture’: the input-intensive crop monocultures and industrial-scale feedlots that now dominate farming landscapes. The uniformity at the heart of these systems, and their reliance on chemical fertilizers, pesticides and preventive use of antibiotics, leads systematically to negative outcomes and vulnerabilities. What is required is a fundamentally different model of agriculture based on diversifying farms and farming landscapes, replacing chemical inputs, optimizing biodiversity and stimulating interactions between different species, as part of holistic strategies to build long-term fertility, healthy agro-ecosystems and secure livelihoods, i.e. ‘diversified agroecological systems’.